Right now I have el cheapo Ruby 6L6's in my Mark III. They seem to run much cooler than the Electro-Harmonix that I am the most partial to (this may also be in part to my 5 watt screen grid resistor upgrade). However, bass travel is a bit flubbier, not necissarily in a bad way; it's more present just not as tight as the EHX. Highs are smooth and not piercing. Mid's are definitely more brittle and "cheaper" sounding; especially since i'm running $$$ preamp tubes. Dynamics are a 7/10. Very great for cleans though; full sounding.
I will say this; I didn't use to play my PGM301 through my Mesa because with EHX 6L6's it was too high pitched and piercing, and with the Ruby's it sounds fat and full bodied...totally a dynamic shift for a maple necked guitar. I was incredibly surprised.