Hi
I have this setup so happy to answer any questions you might have.
Rig: Mark V running 4 cable method into Axe FX, going into Torpedo reload out to both recto cab and apogee interface.
I kind of went full circle on this, initially wanted the axe just for the effects, started using the amp models in the setup and after a few months went back to full mesa for amp with Axe mainly for reverb / delay and chorus. The amp models are great and there if needed but nothing is comparing to the real thing to my ears. Could be all in my head.
After I stopped using the modelling I toyed with the idea of downscaling the axe fx but the versatility of all the inputs / outputs and switching means it's likely to be permanent fixture for me. If you do this though you'd definitely want to get a foot controller. I use the Behringer FCB1010 which is relatively cheap but allows me to change amp channel, axe preset and toggle on and off certain effects. Without this would be far more difficult to actually integrate in and only set me back a $100 compared to the $600-$1000 Fractal controller.