This thread is a good read, getting some ideas from it. And I got some settings ideas from some of the other threads too, heading into a weekend practicing with 3 bands in 3 days so excited to try out some new things.
I use an EC Pedals switcher for channel changing and looping the pedals, all the pedals are front of the amp. Channel 1 doesn't get any playing time in my current projects, but I love to get big ringing semi overdriven sounds out of it before and after practice. Channel 2, is Crunch, gain dimed, gets a little air time. Channel 3 is Extreme, for a thick, saturated metal(ish) sound. EQ is always on in a constantly changing Mid Scoop, Reverb is always off (except with Ch1 on occasion). Les Paul Traditional with an SD Invader in the bridge.
Effects, I like to think I have a blue-collar attitude towards them, I mostly stick with simple, easy to acquire classic effects for their classic sounds.
Loop 1: ISP Decimator
Loop 2: Boss SD-1 OD - gain low, volume high, tone varies
Loop 3: MXR Phase 90 - regular block style, in the EVH position
Loop 4: Boss CE-3 - an early one, rate and depth dimed
Loop 5: TCE Alter Ego - I change settings between the digital, analog and tape voices -or-
Loop 5: MXR Carbon Copy - depending on my mood/band, both delays are usually set for long, loud repeats
For main rhythm sounds; the Decimator is on, Channel 3 and that's it. I have presets to throw in either the Boss OD or Chorus when I want to thicken/liven it up.
When I use Channel 2, it's; Crunch, Decimator on, Boss OD on, everything else off.
For leads; the switcher turns on the MkVs Solo boost, Channel 3, the Decimator comes off, I have presets for dry solo, one with Phaser only, one with Delay only.
This set up gets me through 3 sets of Thrash/Crossover, Cutting Classic/Modern Punk, Classic 70s-80s Punk Covers.
I wouldn't want to try any of this without the MkV, the V makes it all perfect!