You will be better off if the Mark V is a bit newer... There was a tone stack change in 2010 on CH3 preamp to cut back on too much treble and such.
If you find that CH3 is a bit icy there is a simple fix for that too (just a tube swap).
I generally play everything and use all of my amps for that purpose. I am really digging into the blues lately or running just the clean channel but still love to get into some early 70's stuff like ACDC or Led Zeppelin. All of the amps on my sig will do that quite well.
My top two amps are the JP-2C and the TC-50. Definitely there is a huge difference between the two in tone but they can sound similar if you dial one to match the other (sort of). It all depends on how loud I want to play. I find the TC-50 easier on the ear due to the master volume control. That amp is so much fun to play, just as much fun as the JP-2C. For either amp (in head format, JP-2C is head only, TC-50 you have options) I would recommend the Mesa Vertical 212 cab.
For the Mark V, I have struggled with it over the years I have owned it. I had bought it in late November of 2012. I have had it much longer than the TC-50 or the JP-2C. I have also had a Mark III new from 1987 until October of 2012 and a Mark IV from 2000 until May of 2015. Never had any issues with the III or the IV. Both amps have served me well and the Mark III went to a good home and is still in use today. Not sure what happened to the Mark IV as I sold that to Sam Ash as I was building up a studio and drum kit at that time. I decided to keep the Mark V due to its features and versatility. I had other amps to cover the high gain style of music when I want to play Heavy Metal as well as other styles of music. The JP-2C cured my woes for what I was missing after selling the Mark III and the Mark IV, and it gave me far more that what I could get from the Mark V, that is until the "saturation mod" thread was started and all that changed. Mark V is a good amp to get. I would find it very difficult to decide on just one (V, JP or TC).
At the moment I would rate in favoritism: TC-50, JP-2C, Mark V. Of course that will shift depending on what I want to play. All three will do the blues but the leader of them would fall on the TC-50. For an acoustic sound (even better if your guitar has piezo bridge) that goes to the Mark V clean. Crunch would be all three. The amp with the most tube choices: TC-50 (6L6, EL34, 6V6), Mark V (6L6, EL34), JP-2C (6L6).
The Mark V has the most versatile power supply (full power/Variac, 90W, 45W, 10W, each channel can be set to individual power settings but the full/variac is global and will affect all three at the same time). JP can be set to 100W or 60W (global setting). TC-50 is just 50W but can run to 25W with the 6V6 tubes. The Mark V probably has the most features of the three. However the JP and TC have some other things that make them attractive.
I would even recommend the Roadster too or even the RA100. Actually most amps will work well for all venues and styles of music. If you were really into country style of music the amps on the list will suffice but the LoneStar may be a better choice.
Out of the 3 amps in question (JP, TC and MKV) they will perform quite well with all types of guitars. Hollow body types may serve well with the TC-50 (I have played a semi-hollow body guitar when I first tried a TC-50 and actually liked it more than I expected). Single coil or humbucker guitars, set neck, neck though and bolt on all work equally well with all of them. If you were looking to add a bit of OD or just a bit of saturation but not so much to get muddy the Mark V and JP really do well with pedals up front.
Roll the dice or flip a few coins. They are all good amps.... As for the 5:50, never played though one....