I would say you can go in 2 different directions with it,
The first one is what MrMarkIII has said (a lot simpler for the reasons he has mentioned -a single preamp to control)
The second one would be a spliter before both preamps (a lot more complicated if you wanna use the 3 channels on both etc) But you can use both preamps to colour each amp in a different way and complement each other...
If its for live applications with 2 Mk3's I would go with the first option. If it's for studio stuff probably with the second one (even mixing R2 on one of them with lead and R1 on the other) but depending on what you want and what may work best in a particular situation...
If I'm not wrong John Sykes used 3 (yes THREE) MkIII coliseum heads (one of them with an open wah as a tone filter in front) for the recording of Whitesnake's 87 album... I think the guitar sound on that album is pure evil!. :twisted:
Cheers