For example, I saw your other post... for "optimal" sound quality, I'd suggest that your wireless receiver goes into your tuner, into your flanger, and then into the input jack. Then, put your delay pedal in the effects loop.
For a slightly different sound, change it to wiress into tuner into input jack. Then put your flanger and delay (in that order) in your effects loop. Typically flanger gets put before the input jack, but a chorus pedal can sound really nice as the first item in the FX loop before delay and digital reverb units.
I agree with you. On the other thread, I made the same statement originally, although, I was tired at the time and may not have worded it as well. I was also telling AliensExist4 to experiment, to see what he personally liked best. Then, I also gave the easiest way to setup, which will at least get him started.
I have a GT-6 that is collecting dust, as I found that individual pedals on a pedalboard were both the most convenient and best sounding to me. It's much quicker to do "on the fly" adjustments when all of the knobs are right in front of you, rather than trying to reprogram a multi-effect. Also, as written above, if you find another effect you like, you can either just add it or replace something else.
I currently have the pedal board that is split into two chains, so that one chain (Tuner, Compressor, and Overdrive) are going straight in to the amp's input, and my modulation effects (Chorus, Tremelo, and Delay) are fed into the effects loop. This setup sounds the best to me.
I started out by feeding everything straight to input in the past for convenience and two less cables. It doesn't sound quite as good, but works. And have since been using this split method.