I'm using a Fender American Standard HSS (The Ash bodied option, with a maple fingerboard) as my main guitar with the DC-5 combo which I setup like so:
DR, T, M, B, P, R, M
Clean- 5, 4, 6, 4, 4.5, 5, 6.
Drive- 4, 6, 6.5, 2, 0, 2, 4.
I keep an OD, a Compressor and a Delay on a pedalboard and...