I went the combo route mostly because it's more compact and easier to handle (not talking about the weight, obviously). I didn't realize the 1x12" combo was THAT heavy when I first ordered it, but it was a lot cheaper that a head and 2x12" cab setup (they don't import the 1x12" Lonestar cab here), plus since the combo has casters, I thought that would mostly resolve the weight problem, which it did. I find myself able to just push the amp on it's wheels at most places, and if I need to lift it or carry it, I usually manage get someone to assist me if it's to heavy. So at least so far I haven't encountered any real issues with it's weight, but I can certainly see how a head and cab setup would be more beneficial in some cases.
If I was able to pay the extra money for a head and a cab (something which was financially impossible for me at the time I bought the amp), I'd probably do so. But I'd really like those extension cabs to come with casters, though.