To use or to not to use the Triaxis FX loop?

I seen some information on this board about it. Namely that the Triaxis's FX loop is in between the 4th and 5th tube along with the dynamic range? I realize, all depends on what one wants and there is no "correct" answer but what about a rule of thumb?

I am about to change up my rig with having the following equipment and one thought is to do it like this. Any thoughts on your guys end are greatly appreciated.

Guitar --> Triaxis --> Triaxis FX loop out --> Mark L Custom Line Switcher --> into Triaxis Stereo Return --> 2:90.

In the Mark L Custom Line Switcher to have a Line 6 Filter Pro, Line 6 Mod Pro, and the Line 6 Echo Pro in it.

I'd experiment with using the effects loop and trying it between the Triaxis and 2:90, then choose which ever sounds best/is more practical (depending on your priorities).