I've used the 4CM with my Axe-FX Ultra and the JP-2C. I'm not entirely sure how unity gain works on the Ultra vs the II, but I have my knobs on the front like so:
In 1 - Noon In 2 - 2:30 Out 1 - maxed Out 2 - maxed
It seems to work pretty well, though my guitar has been picking up the Mesa's transformer sometime with higher gain settings. Reducing in 2 helps a little, but it's tough in shred mode or boosted, maxed gain.
_________________ EBMM JP7 JP-2C | Recto 2x12 Vertical AXE-FX Ultra | MFC-101 Mk III
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