I have noise on all channels, more so with higher gain settings (love the clean channel when it gets dirty).
Noise is present with or without any instrument plugged in, with or without reverb too. It is typical power supply noise and is common with most if not all tube amps unless you have a noise gate on the amp. This issue may be related to the impedance of the power tubes as I have noticed a difference in noise levels with different power tubes. Seems to be more pronounced with EL34 than the 6L6 option but still present either way. I too use the power soak most of the time, but often like to feel the music as well as hear it so I will go all out on occasion. Sometimes changing the PI tube may reduce the noise level to some degree. I do like the tone of the Mesa 12AX7A for the PI tube but I have also had good results with a Sovtek LPS (long plate) for the PI. I will have to put one back in the RA100 and listen for a difference in noise levels.