Yes! They're actually one of the best amps there is for thrash. Very evil sounding if that's what you're after. The amp is a Marshall killer but also works well in conjunction with Marshall amps taming the shcrillness of the Marshall. Kinda like mixing Celestion speakers with Electro-voice speakers.
Take a look at the sample setting for Metal. Note that the presence control is recommended at 10, mids at 0 and bass at 2.5. Of course the GEQ is essential IMO in getting the best out of a Boogie, YMMV but the GEQ in the loop ain't the same.http://mesaboogie.com/media/User%20Manu ... %20III.pdf
These amps have so many tones you can easily get bad tone if you're not careful. It is imperative that you read the manual to understand how the controls work. For Metal, the bass should never go above 3. The classic V GEQ setting will give you the bass back and a real awesome Metallica/Pantera tone all day long.