I tend to prefer (closed back) 4x12s to smaller cabs because I like a huge sound at any volume. Smaller cabs seem more beamy / focused. The weight doesn't really bother me.
I have read with the 12L that a 4x12 is a large amount of overkill since they are 200w speakers, and that a Thiele matches it well and is plenty loud, but they are very beamy.
My favorite setup is a Thiele loaded with an EV12L combined with an open back 1x12 loaded with an Eminence MS-12.
I don't find the EV all that beamy in the Thiele but then again I rarely (if ever these days) use that cab alone.
I have 4x12's and 2x12's with similar configurations (EV's in the closed back bottom and MS-12's in the upper open back) and like these cabs as well.
I have tried many different speaker configurations in all these cabs (1x12's Thiele's, 2x12's, 4x12's).
The C90 in the open back part of a 2x12 or 4x12 as well as the lone speaker in a 1x12 works for many when combined with a closed back cab loaded (Thiele etc) with the EV-12L. I personally have mixed feelings about the C90. Sometimes they sound ok to me other times they sound too ice-picky.
In any case I keep going back to the EV/MS-12 combination for use with my amp (C+) and guitar (has PAF type humbuckers).