To end the "I'm the big, smart guy" run and return the thread to the amp stuff, I just want to add that Mesa's fixed bias system definitely wins for being the more practical.
BUT - any amp can benefit from a bias adjustment, it's like a "necessary evil" if you want to "trim" the amp to your likings. I think it makes more of a difference than tube brands, for example (if the change is not-so-subtle), but it can also destroy an aspect of your amp - you'd end up with a killer drive and would be left with a sh!t clean tone, so there is a lot of room for error.
I have 2 questions (hope this doesn't become a thread-jack):
1. What are the the "normal" milivolt values for a healthy dissipation percentage for 6L6s (about 40-45mV per tube, from what I read)? I'll be helping my badmate bias his 6L6 amp after he retubes it and I don't want to screw it up by yanking the bias too high/low.
2. OP - how did it affect your clean tone/clean headroom? I found that higher bias made my JVM's clean a bit darker...