I would. Here's a video that I did using Amplitube Mesa Boogie. For the rhythm guitars, they are Amplitube Mesa Boogie, Engl, and I used the Kemper. But the solos are 100% Amplitube Mesa Boogie, using the Mark IV model. I'm sure there are a lot of people that will say they can tell the difference, and maybe they can, but I am happy with the results. I've been a Mesa owner for 24 years using the Mark IV and Dual Rectifiers. I think Amplitube did a great job. Each of those amps react the same way the real amps do, with everything that I do like and even the characteristics that I don't.
https://www.youtube.com/watch?v=xDhemfexyDg